https://www.kimbroughlab.com/upcoming-events daily 0.75 2020-07-18 https://www.kimbroughlab.com/upcoming-events/event-five-mb7xy monthly 0.5 2020-06-24 https://www.kimbroughlab.com/upcoming-events/event-four-dztjj monthly 0.5 2020-06-24 https://www.kimbroughlab.com/upcoming-events/event-three-3xndc monthly 0.5 2020-06-24 https://www.kimbroughlab.com/upcoming-events/event-two-sg53g monthly 0.5 2020-06-24 https://www.kimbroughlab.com/upcoming-events/event-one-3jyj6 monthly 0.5 2020-06-24 https://www.kimbroughlab.com/news daily 0.75 2024-08-22 https://www.kimbroughlab.com/news/new-lab-members-3 monthly 0.5 2024-08-22 https://www.kimbroughlab.com/news/new-publication-3 monthly 0.5 2024-03-14 https://www.kimbroughlab.com/news/new-funding-5 monthly 0.5 2023-12-10 https://www.kimbroughlab.com/news/new-lab-members-2 monthly 0.5 2023-07-19 https://www.kimbroughlab.com/news/new-publications-2 monthly 0.5 2023-07-19 https://www.kimbroughlab.com/news/new-lab-member-2 monthly 0.5 2023-01-04 https://www.kimbroughlab.com/news/new-publication-2 monthly 0.5 2022-11-28 https://www.kimbroughlab.com/news/new-publication-1 monthly 0.5 2022-11-07 https://www.kimbroughlab.com/news/lab-recieves-r01-award monthly 0.5 2022-09-21 https://www.kimbroughlab.com/news/new-lab-members-1 monthly 0.5 2022-08-25 https://www.kimbroughlab.com/news/new-funding-4 monthly 0.5 2022-06-22 https://www.kimbroughlab.com/news/new-funding-3 monthly 0.5 2022-04-09 https://www.kimbroughlab.com/news/new-publication monthly 0.5 2022-04-09 https://www.kimbroughlab.com/news/new-funding-2 monthly 0.5 2022-01-06 https://www.kimbroughlab.com/news/new-publications-1 monthly 0.5 2021-10-01 https://www.kimbroughlab.com/news/new-lab-members monthly 0.5 2021-09-14 https://www.kimbroughlab.com/news/new-lab-member-1 monthly 0.5 2021-08-04 https://www.kimbroughlab.com/news/new-publications monthly 0.5 2021-05-18 https://www.kimbroughlab.com/news/new-lab-member monthly 0.5 2021-08-04 https://www.kimbroughlab.com/news/new-funding-1 monthly 0.5 2021-03-25 https://www.kimbroughlab.com/news/news-update-1 monthly 0.5 2021-03-25 https://www.kimbroughlab.com/news/news-update monthly 0.5 2021-02-18 https://www.kimbroughlab.com/news/new-funding monthly 0.5 2021-02-11 https://www.kimbroughlab.com/news/welcome-new-lab-member monthly 0.5 2021-02-11 https://www.kimbroughlab.com/news/igqi1sq7w9dkn7i6gy2jlzl6tzxwqp monthly 0.5 2021-02-11 https://www.kimbroughlab.com/news/purdue monthly 0.5 2020-09-21 https://www.kimbroughlab.com/lab-members daily 0.75 2026-02-17 https://images.squarespace-cdn.com/content/v1/5f135c8d59262a257d75329c/1597975896389-J2RLE93UECHQNZOIS29W/KimbroughCroppedPhoto.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5f135c8d59262a257d75329c/1628050666948-7OASQMR15X5ZE5E5TT91/Picture1.png Lab Members https://images.squarespace-cdn.com/content/v1/5f135c8d59262a257d75329c/d87e66b2-c693-49ff-a054-5830abb66e00/IMG_2716.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5f135c8d59262a257d75329c/6bab7fc5-45a1-42b2-be66-b8b286d6c2c7/image+%2820%29.png Lab Members https://images.squarespace-cdn.com/content/v1/5f135c8d59262a257d75329c/a14116a5-47cf-47ae-a2b4-2b16f30559af/%E6%88%AA%E5%B1%8F2024-08-28+12.36.08.png Lab Members https://images.squarespace-cdn.com/content/v1/5f135c8d59262a257d75329c/88d73994-701c-48db-8eb1-cb099b1f614c/cd87f8a18nd013c7758343977f1d9d38.jpg Lab Members https://www.kimbroughlab.com/mission-statement daily 0.75 2020-08-21 https://images.squarespace-cdn.com/content/v1/5f135c8d59262a257d75329c/1595119350560-KH0VIID4N12A6WXRCC8F/pill-3673649_1920.jpg Mission Statement - Understanding brain and behavior to overcome addiction. Substance use disorders are a major issue worldwide, but our understanding of brain changes that are caused by drug use is limited. Overall, the labs research seeks to understand the effects of behavior (e.g., drug use) on states of neural activity throughout the whole brain (i.e., neural networks) and, conversely, the effects of manipulating these neural networks on behavioral outcomes. Additionally, it is critical to further our understanding of drug use using valid translational preclinical approaches. The laboratory to uses valid translational behavioral models of substance use disorders that are paired with chemogenetics, whole-brain imaging and network analysis. — Adam Kimbrough Principle Investigator https://www.kimbroughlab.com/research-projects-1 daily 0.75 2020-09-09 https://images.squarespace-cdn.com/content/v1/5f135c8d59262a257d75329c/1598044864428-WTQYYUY3BWTAY02SDQK0/image-asset.jpeg Research Projects - Neural networks and circuits involved in excessive alcohol drinking One of the laboratories projects seeks to determine whether alcohol dependence leads to remodeling of functional connections in the brain and to identify a causal role for novel brain regions and pathways that are involved in the motivation for excessive drinking and withdrawal symptoms. This project uses a well-established mouse model of alcohol dependence (two-bottle choice/chronic intermittent ethanol vapor [CIE]), chemogenetics, and cutting-edge whole-brain imaging (iDISCO+) in combination with graph theory analysis of neural network properties. We have previously shown that alcohol dependence alters neuronal networks to restructure the brain and severely reduce brain modularity. Additionally, we identified several brain regions that have been overlooked previously in research related to alcohol abstinence and drinking behavior. These regions include: the tuberal nucleus, parasubthalamic nucleus, cortical amygdala, and intercalated amygdala. The lab plans to examine these brain regions using chemogenetic disruption in order to assess whether these regions are critically important in the motivation for excessive alcohol drinking and withdrawal symptoms. https://images.squarespace-cdn.com/content/v1/5f135c8d59262a257d75329c/1598044766830-G10M13P4WLWDZEOKYLA7/image-asset.jpeg Research Projects - Understanding brain activity associated with oxycodone withdrawal Oxycodone use disorder has become a nationwide epidemic. Changes in brain activity that are caused by oxycodone withdrawal are not well understood. We seek to use whole brain/network analysis approaches to examine the consequences of oxycodone use and dependence on brain activation. We seek to identify brain regions and circuits that may be involved in oxycodone use disorder that may be similar to or different from other substance use disorders. We will compare the neural network of oxycodone withdrawal across drug use methods (e.g. forced intake and voluntary self-administration). Further, we will compare the network formed by oxycodone withdrawal to other opioids to look for similarities and differences in brain structure and function. https://images.squarespace-cdn.com/content/v1/5f135c8d59262a257d75329c/1599686926654-5E0TIXV263TPLZR3F4AL/drugs-3874188_1280.png Research Projects https://images.squarespace-cdn.com/content/v1/5f135c8d59262a257d75329c/1598047872325-PB4C0401UGM9VDS92J4E/image-asset.jpeg Research Projects https://www.kimbroughlab.com/contact daily 0.75 2022-08-12 https://www.kimbroughlab.com/publications daily 0.75 2025-03-18 https://www.kimbroughlab.com/home daily 1.0 2025-11-20 https://images.squarespace-cdn.com/content/v1/5f135c8d59262a257d75329c/1597785350626-EZ3WEIMVX8JVKY58I2TN/image-asset.jpeg Home - Research Projects Substance use disorders are a major issue worldwide, but our understanding of brain changes that are caused by drug use is limited. Overall, the labs research seeks to understand the effects of behavior (e.g., drug use) on states of neural activity throughout the whole brain (i.e., neural networks) and, conversely, the effects of manipulating these neural networks on behavioral outcomes. https://images.squarespace-cdn.com/content/v1/5f135c8d59262a257d75329c/1595188608931-QQT2HW6VQHZQDGTJUQT0/PVN+DL+Composite+Figure.jpg Home - Laboratory Techniques It is critical to further our understanding of drug use using valid translational preclinical approaches. The laboratory to uses valid translational behavioral models of substance use disorders that are paired with chemogenetics, whole-brain imaging and network analysis. https://www.kimbroughlab.com/donate daily 0.75 2020-08-18 https://www.kimbroughlab.com/join daily 0.75 2025-04-21 https://www.kimbroughlab.com/techniques daily 0.75 2023-05-04 https://images.squarespace-cdn.com/content/v1/5f135c8d59262a257d75329c/1600377401762-IDEMUA3MAUPCGXKQHSIE/vapor+chambers.png Techniques https://images.squarespace-cdn.com/content/v1/5f135c8d59262a257d75329c/1600200474578-KAZ3LXB5K0V9PUB6HHSB/Irritability+Illustration.png Techniques https://images.squarespace-cdn.com/content/v1/5f135c8d59262a257d75329c/1600200526771-NBXP06XYT9SQJNI0ACUD/CeA+DL+Composite+Figure.jpg Techniques https://images.squarespace-cdn.com/content/v1/5f135c8d59262a257d75329c/e938159e-1dcd-4083-9154-fba42b80cbfc/Screen+Shot+2023-04-25+at+12.47.22+PM.jpg Techniques https://images.squarespace-cdn.com/content/v1/5f135c8d59262a257d75329c/1600200376565-2SVP9E1BDP8UQ1C91HYP/figure_opt2.png Techniques https://www.kimbroughlab.com/lab-photos daily 0.75 2022-08-11 https://images.squarespace-cdn.com/content/v1/5f135c8d59262a257d75329c/d97edcec-ab24-4384-9668-2154d3a55056/YueyiRSA.jpg Lab Photos https://images.squarespace-cdn.com/content/v1/5f135c8d59262a257d75329c/af8f0956-5dcb-4a6f-9e35-9c4ade696daa/TiangeRSA1.JPG Lab Photos https://images.squarespace-cdn.com/content/v1/5f135c8d59262a257d75329c/de71661e-eca1-465c-9756-c508e59d7db4/AlyssaRSA1.jpg Lab Photos https://images.squarespace-cdn.com/content/v1/5f135c8d59262a257d75329c/0e577a13-cc0a-46f0-9e15-c8423b1aab4a/AlyssaRSA2.jpg Lab Photos https://images.squarespace-cdn.com/content/v1/5f135c8d59262a257d75329c/9db3a451-62ee-49a5-8700-057e8700715e/Mariana.jpg Lab Photos https://images.squarespace-cdn.com/content/v1/5f135c8d59262a257d75329c/c32a75d7-c24d-4f43-b59f-9658b9525693/Image+from+iOS+%285%29.jpg Lab Photos